Global settings ignored with client setting

refferring also to:

But my Default Path is now:
C:|C/optional;D:|D/optional;E:|E/optional;E:|E/optional
Just to not get the backup process error for that reason I switched drive letter E to another one on my PC (Drive Letter E was before a DVD Drive).

Restarting server now completely and windows PC, too.

I am having the following exclusion list:
C:\WINDOWS\system32\LogFiles\WMI\RtBackup\:.:;C:\Users\:\index.dat;C:\WINDOWS\Minidump\*;:\Pagefile.sys;C:\WINDOWS\system32\MSDtc\MSDTC.LOG;C:\WINDOWS\netlogon.chg;:\hiberfil.sys;:\System Volume Information\*;C:\ProgramData\Microsoft\Windows\WER\*;C:\WINDOWS\softwaredistribution\*.*;C:\ProgramData\Microsoft\Network\Downloader\:;C:\WINDOWS\CSC\*;C:\WINDOWS\System32\Bits.log;C:\WINDOWS\System32\Bits.bak;C:\Users\:\AppData\Local\Temp;C:\Users\:\AppData\Local\Microsoft\Windows\Temporary Internet Files;C:\Users\:\AppData\Local\Google\Chrome\User Data\Default\Cache;C:\Users\:\AppData\Local\Google\Chrome\User Data\Default\Media Cache;C:\Users\:\AppData\Local\Microsoft\Windows\Explorer\thumbcache*;C:\Users\:\AppData\Local\Mozilla\Firefox\Profiles\:\cache2;C:\Users\:\AppData\Local\Mozilla\Firefox\Profiles\:\cache;C:\Windows\Temp;:\$Recycle.Bin;:\System Volume Information;C:\Windows.old;C:\Windows;C:\Program Files;C:\Program Files (x86);C:\ProgramData;*\Nextcloud\*;*\OneDrive\*;*\OneDriveTemp\*;*\AppData\Local\Microsoft\WindowsApps\**;*\AppData\Local\Packages\*;:\$Windows.~BT;*\AdwCleaner\FileQuarantine\*;*\AdwCleaner\RegistryQuarantine\*;*\AdwCleaner\Quarantine\*

Should I add *\HarddiskVolumeShadowCopy* to the exclusion?