Add it to the FilesNotToSnapshot registry key ( https://docs.microsoft.com/en-us/windows/desktop/backup/registry-keys-for-backup-and-restore#filesnottosnapshot , https://docs.microsoft.com/de-de/windows/desktop/VSS/excluding-files-from-shadow-copies). Microsoft does this for normal Windows updates for example.
(It will delete all the files in this directory and there are a lot of files… so you’ll have to evaluate the performance or if it runs into timeouts with that)