I think we need a thread for file exclusions that we have had to put in place, so that they might possibly be included in future releases as a configuration option. @uroni can weigh in on these, as if he UrBackup is doing VSC backups I would not think they would cause a problem, but they have for me.
Here are ones that I have run across that have caused problems for my backups and are safely excluded (I think, YMMV):
On Server 2012 and Server 2012R2 that have dedup enabled, not excluding this directory from backups always seems to cause them to fail. I believe, and correct me if I am wrong, that it can be safely excluded as UrBackup backs up the file in the non-deduped state.
QuickBooks network settings. These change constantly as clients connect and disconnect. Not necessary in order to restore QuickBooks, so I set an exclusion for them.
Are there any others that people have fun across?