Changing the settings on the server side - Excluded from backup

i have a question about a specific settings change on server side,
We need to push a change to all clients, previusly we had list of exeptions in file backup that we typed both into server side and client side of Urbackup which included C:/Program files,
now we need to include C:/Program files in our backups because some aplications save data in there and question is:
if server side settings change - specifically “Allow client-side changing of the directories to backup”
and we update list of exeptions, will clients automatically update their settings - will they listen to server settings or do we have to manually do over 50 clients in this case ?