I’m on Win 10 Pro [1909], Intel i5 5th gen, 24GB RAM, RAID5 12TB in total for backups + 120GB SSD for Windows OS. Virgin broadband 320Mbs/20Mbs down/up and 41 clients incl. Hyper-V hosts and image backups over the Internet + 1 local. It works.
No to built-in compression. Problems with images. File deduplication on Win server 2019 worked saving bit less than 20% but getting another 4TB HDD was cheaper that Win Server license.