Multiple machines failing /w disk errors and virus warnings

Various backups are still failing after applying the changes suggested by silversword. Additionally, the D:\urbackup directory has been excluded from our anti-virus console. Any other ideas?

ERROR: Error opening file “\?\D:\urbackup\Infinity Dallas - Dr. Patel\180618-2103.b68xO+K9SCOF35cLk4Bf9Q\25” for reading file. File: temp_fn. Operation did not complete successfully because the file contains a virus or potentially unwanted software. (code: 225) Target path: “D:\urbackup\Infinity Dallas - Dr. Patel\180618-2103\C\xperver.exe”
ERROR: Error opening file “\?\D:\urbackup\Infinity Dallas - Dr. Patel\180618-2103.b68xO+K9SCOF35cLk4Bf9Q\16045” for reading file. File: temp_fn. Operation did not complete successfully because the file contains a virus or potentially unwanted software. (code: 225) Target path: “D:\urbackup\Infinity Dallas - Dr. Patel\180618-2103\C\Windows\System32\xperver.exe”
WARNING: Not all folder metadata could be applied. Metadata was inconsistent.
ERROR: FATAL: Backup failed because of disk problems (see previous messages)